Structural events in insulin and IGF signalling - a nanodisc approach to a problem in cancer, diabetes and Alzheimer's disease

胰岛素及其胰岛素样生长因子在澳大利亚老年人面临的三种主要疾病状态--糖尿病、癌症和阿尔茨海默病--中发挥着重要作用。我们的目标是了解这些蛋白质是如何通过它们所谓的受体向细胞发送信息的。我们将从细胞中分离出受体分子，然后在先进的电子显微镜中对它们进行成像，以产生三维图像。我们的发现将对设计针对上述三种疾病的治疗方法具有一定的指导意义。

Insulin and its insulin-like growth factors play a major role in three major disease states facing ageing Australians—diabetes, cancer and Alzheimer's disease. We aim to understand how these proteins send messages into cells via their so-called receptors. We will isolate the receptor molecules from cells and then image them in an advanced electron microscope to produce three-dimensional images. Our findings will have implications for the design of therapeutics targeting the above three diseases.