Structural and functional characterisation of the oncogene P-Rex1

癌症扩散到身体其他部位(转移)是死亡的主要原因。因此，确定调控转移的蛋白质的特性是当务之急。P-REx1在促进乳腺癌和其他癌症的转移中起着至关重要的作用。我们将确定P-REx1活性的结构基础，并研究其失调如何促进细胞异常生长。这项研究将为建立针对癌症P-REx1的未来药物开发计划提供知识。

The spread of cancer to other parts of the body (metastasis) is a major cause of mortality. The characterisation of proteins that regulate metastasis is therefore a priority. P-Rex1 plays a crucial role in promoting metastasis in breast and other cancers. We will determine the structural basis of P-Rex1 activity, and investigate how its dysregulation promotes aberrant cell growth. This study will provide the knowledge to build future drug development programs targeting P-Rex1 in cancer.