Studies of Cullin 5 deficiency for novel insights into SOCS redundancy and specificity

细胞因子是调节血细胞生产和功能的荷尔蒙。本申请中提出的研究重点是一种重要的蛋白质家族的生物学作用和生化作用机制，这些蛋白质控制细胞因子的活动，从而使它们在协调氧气运输、血液凝结和对感染的反应方面发挥有益作用，同时防止过度反应的有害影响，如骨髓增生性疾病或自身免疫。

Cytokines are hormones that regulate blood cell production and function. The research proposed in this application focuses on the biological roles and biochemical mechanisms of action of an important family of proteins that control the actions of cytokines, thereby allowing their beneficial effects in coordinating oxygen transport, blood clotting and responses to infection, while preventing the harmful effects of excess responses, such as myeloproliferative diseases or autoimmunity.