Superoxide and the nitric oxide-peroxynitrite pathway in renal ischaemia-reperfusion injury

急性肾衰竭是常见的，死亡率为50%。自由基是一种非常活泼的不稳定分子，能改变正常的新陈代谢反应。本研究旨在确定氧自由基和一氧化氮的作用及其相互作用在肾缺血损伤。一氧化氮对血流的积极作用和一氧化氮与超氧自由基（过氧亚硝酸盐）反应的副产物对肾小管的破坏作用之间的平衡可以决定细胞损伤的程度，从而从缺血性和缺氧性肾损伤中恢复。这些相反的力量的调制可能会导致策略，以保护和改善急性肾功能衰竭的人。

Acute renal failure is common and has 50% mortality. Free radicals are vey reactive, unstable molecules that alter normal metabolic reactions. The study aims to determine the role of oxygen-derived free radicals and nitric oxide and their interaction in renal ischaemic injury. The balance between the positive effects of nitric oxide on blood flow and the damaging effects of by-products of the reaction of nitric oxide with superoxide radical (peroxynitrite) on renal tubules may determine the extent of cell damage and hence recovery from ischaemic and hypoxic renal injury. Modulation of these opposing forces may lead to strategies to protect and improve renal function in acute renal failure in man.