Targeting GDNF family ligand (GFL) signalling to treat inflammatory bone pain

与骨髓水肿综合征、骨髓炎、骨关节炎、骨折和骨癌相关的疼痛给澳大利亚和世界各地的个人和医疗保健系统造成了重大负担。在这项应用中，我们将探索我们在神经中识别的编码骨痛的特定信号通路。这将为合理设计高度特异的药物提供机会，这些药物能够专门与在这些条件下驱动疼痛的分子相互作用。

Pain associated with bone marrow oedema syndromes, osteomyelitis, osteoarthritis, fractures and bone cancer causes a major burden on individuals and health care systems in Australia and worldwide. In this application, we will explore specific signalling pathways that we have identified in nerves that code bone pain. This will provide an opportunity for the rational design of highly specific drugs capable of interacting exclusively with molecules that drive pain in these conditions.