Targeting PD-1 expressing T-peripheral helper (Tph) cells and dysregulated checkpoint molecules: Improving outcomes in Rheumatoid Arthritis

类风湿性关节炎是一种慢性疾病，会导致关节疼痛、肿胀和不可逆的畸形。我们建议研究驱动这种疾病的免疫细胞环境。我们将特别关注一种叫做Tph细胞的新型细胞及其相关的免疫途径。我们还将研究如何将它们用作治疗靶点或作为监测疾病活动的标记物。我们的发现可能会转化为临床实践，并形成新的治疗策略的基础。

Rheumatoid arthritis is a chronic disease, causing pain, swelling and irreversible deformity of the joints. We propose to investigate the immune cell environment that drives this disease. In particular, we will focus on a new type of cell called Tph cells and related immune pathways. We will also study how they may be used as therapeutic targets or as markers to monitor disease activity. Our findings may translate into clinical practice and form a basis for new therapeutic strategies.