Targeting remodelling in chronic obstructive pulmonary disease (COPD), chronic asthma and idiopathic pulmonary fibrosis (IPF)

肺病(肺气肿、哮喘和肺纤维化)是澳大利亚社区和经济的主要负担。呼吸道重塑/损伤是所有这些疾病的一个关键特征。患者出现严重的呼吸困难，严重影响生活质量，并经常导致死亡。我们将在实验模型中评估新靶点(包括IL-33)和治疗在抑制创伤方面的潜力。这可能导致一种新的治疗方法来逆转或预防肺部疾病。

Lung diseases (emphysema, asthma & pulmonary fibrosis) are major burdens on Australian community and economy. Airway remodelling/wounding is a key feature of all these diseases. Patients experience severe breathlessness seriously impacting quality of life and frequently leading to death. We will assess the potential of new targets (including IL-33), & therapy in suppressing wounding in experimental models. This may lead to a new treatment to reverse or prevent lung diseases.