Targeting the TWEAK/Fn14 signalling pathway as a novel therapeutic strategy to prevent chronic liver disease progression.

TWEAK/Fn 14信号传导关键调节炎症、纤维化和肝祖细胞反应-所有过程都参与了进行性慢性肝损伤。在这项研究中，我们现在将定义涉及的细胞群，确定潜在的机制，并测试该途径的药理学靶向，作为抑制慢性肝病进展为癌症的新治疗途径。重要的是，我们还将评估我们的发现在人类环境中的可翻译性。

TWEAK/Fn14 signalling critically regulates inflammation, fibrosis and liver progenitor cell responses - all processes involved in progressive chronic liver injury. In this study, we will now define the involved cell populations, identify the underlying mechanisms and test pharmacological targeting of this pathway as a novel therapeutic avenue to inhibit chronic liver disease progression to cancer. Importantly, we will also assess translatability of our findings into the human setting.