Targeting unhelpful pain beliefs to promote physical activity in people with knee osteoarthritis: a multicentre, randomised controlled trial with cost-effectiveness analysis

缺乏运动是膝骨关节炎（OA）患者的一个严重问题：他们缺乏足够的运动来维持健康，而缺乏运动往往会使他们的OA症状恶化。在一项大型临床试验中，我们将测试一种有前景的新疗法——疼痛生物学教育——因为它能改善身体活动和疼痛。我们的试点工作显示了有希望的结果：在139例膝关节OA患者中，这种治疗增加了活动，减少了疼痛，改善持续了长达1年。

Physical inactivity is a serious problem in people with knee osteoarthritis (OA): they are not active enough to maintain their health and inactivity often makes their OA symptoms worse. In a large clinical trial, we will test a promising new treatment – pain biology education – for its ability to improve physical activity and pain. Our pilot work shows promising results: in 139 people with knee OA this treatment increases activity and reduces pain with improvements continuing for up to 1 year.