The role of LINE encoded natural antisense transcripts in immune regulation

遗传信息是地球上所有生命的基础，并被加工成蛋白质，而蛋白质决定了生物体的特征。然而，我们整个基因组中只有大约2%是由编码蛋白质的基因组成的；另外98%是非编码的，其功能仍然不为人所知。本项目旨在利用尖端的基因组技术来产生关于非编码基因组如何调节人类自身免疫性疾病中蛋白质编码基因表达的新知识。

Genetic information underpins all life on earth and is processed to make proteins, which determine the characteristics of an organism. However, only about 2% of our whole genome is made up of genes that encode proteins; the other 98% is non-coding and its function remains poorly understood. This proposal aims to utilize cutting edge genomic technologies to generate new knowledge about how the non-coding genome regulates the expression of protein coding genes in human autoimmune disease.