Therapeutic Targeting of Complement C5a Receptors in HuntingtonÍs Disease
Therapeutic Targeting of Complement C5a Receptors in HuntingtonÍs Disease
批准号:
nhmrc : 1004455
负责人:
A/Pr John O'Sullivan
金额:
$31.23万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
亨廷顿S病是一种遗传性神经退行性疾病,会导致进行性认知和运动障碍,最终导致死亡。本研究旨在探讨免疫和炎症途径在亨廷顿S病患者疾病进展中的作用,以及在该疾病的动物模型中的作用。通过探索这些免疫和炎症途径,我们的目标是找到治疗亨廷顿S病的新治疗靶点。
英文摘要
HuntingtonÍs disease is a genetic neurodegenerative condition leading to progressive cognitive and motor deficits and eventual death. This research aims to explore the role of immune and inflammatory pathways in the progression of disease in patients suffering HuntingtonÍs disease, as well as in an animal model of this condition. By exploring these immune and inflammatory pathways, we aim to identify novel therapeutic targets to treat HuntingtonÍs disease.
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会议论文
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