BEYOND TRADITIONAL GENE BOUNDARIES: Establishing the importance of enhancer epigenetic reprogramming and atypical long-range interactions in cancer cells.

为了战胜这种疾病，仍然需要有效的癌症预防和治疗战略。通过确定前列腺癌细胞中DNA的包装方式与正常前列腺细胞的不同，将使我们能够了解调控中心或工厂的特定位置如何影响基因行为。与癌症的遗传缺陷不同，这些中心对DNA的物理和化学修饰可能是可逆的，这为开发新的治疗方法和诊断工具提供了机会。

Effective prevention and treatment strategies for cancer are still needed to combat this disease. By determining how DNA is packaged differently in prostate cancer cells relative to normal prostate cells, will allow us to understand how the specific location of regulatory centres or factories affects gene behavior. Unlike genetic defects in cancer, physical and chemical modifications to DNA in these centres are potentially reversible, providing an opportunity to develop novel therapeutics and diagnostic tools.