Understanding allosteric modulation and biased signalling at Family B GPCRs

B家族gpcr是治疗骨质疏松症、高钙血症、Paget病、II型糖尿病的药物的治疗靶点，并且正在积极寻求用于其他代表主要全球健康负担的疾病。尽管投入了巨大的资金，但目前还没有口服药物可以作用于这些受体。这说明缺乏对它们如何工作的机械理解。我的研究重点是解决这个问题，以及如何利用这些受体来设计和识别更好的药物。

Family B GPCRs are therapeutic targets for drugs treating osteoporosis, hypercalcaemia, Paget’s disease, type II diabetes and are being actively pursued for other diseases that represent major global health burdens. Despite huge financial input, there are no orally available drugs that act on these receptors. This speaks to a lack of mechanistic understanding of how they work. My research focuses on addressing this question and how to exploit these receptors to design and identify better drugs.