Understanding changes in the mammalian prenylome induced by statins and prenyltransferase inhibitors

异戊烯化是类异戊二烯脂质与蛋白质的共价结合，广泛存在于哺乳动物细胞中。它对蛋白质的正常功能至关重要，有助于癌症和炎症的进展。我们已经开发出一种新的技术来识别细胞中所有的异戊二烯化蛋白质。在此基础上，分析他汀类药物和抗癌药物对蛋白质异戊二烯化的影响。这将为确定其更有效的临床用途提供指导。

Prenylation, the covalent attachment of isoprenoid lipids to proteins, is widespread in mammalian cells. Essential for a protein's normal function, it contributes to the progression of cancer and inflammation. We have developed a novel technology to identify all prenylated proteins in the cell. Aided by this method, we will analyse the effect of statins and anti-cancer drugs on protein prenylation. This will provide guidance in identifying a more effective clinical use for them.