Understanding the contribution of sympathetic overactivity to maternally programmed obesity related hypertension

肥胖和相关疾病在世界范围内呈上升趋势。除了成人的危险因素外，发育过程中所遇到的环境也可能易患后期疾病。我们的数据显示，孕妇的饮食会影响其后代肥胖和高血压的发展，并且交感神经系统会变得失调。该项目将评估孕期母体脂肪摄入如何影响后代的交感神经系统功能，并研究可能的管理策略。

Obesity and associated diseases are increasing worldwide. Aside from adult risk factors, the environment encountered during development may predispose to later disease. Our data shows that the diet consumed by pregnant mothers can influence the development of obesity and hypertension in her offspring and that the sympathetic nervous system becomes dysregulated. This project will assess how maternal fat intake in pregnancy affects sympathetic nervous system function in the offspring and we investigate possible management strategies.