Understanding epilepsy: from genes to neural circuits

癫痫是一种常见的神经疾病，其特征是大脑活动异常，称为癫痫。许多癫痫患者对治疗的反应很差。一个主要原因是，目前尚不清楚单个脑细胞的异常是如何导致癫痫发作的，癫痫涉及大量脑细胞。这个项目将使用建模和实验技术来解决这个问题。更好地了解癫痫在大脑中的发展方式将导致更有效和更有针对性的治疗。

Epilepsy is common neurological disorder characterised by abnormal brain activity known as seizures. Many patients with epilepsy respond poorly to treatment. A major reason is because it is unknown how abnormalities in single brain cells generate seizures, which involve large numbers of brain cells. This project will tackle this problem using modeling and experimental techniques. A better understanding of how seizure develop in the brain will lead to more effective and targeted therapy.