Understanding the parameters of innate immune activation that govern protection during influenza virus and secondary bacterial infection: development of a TLR2-based antimicrobial agent.

下呼吸道感染是世界范围内导致死亡的主要传染病。我们发现了一种化合物，可以减少病毒和细菌感染造成的影响和疾病。本研究将开发该制剂预防甲型流感病毒传播和继发性细菌性疾病发展的能力。此外，我们将确定该化合物的作用机制，以及它作为一种广谱干预措施对抗病毒和细菌感染的效用。

Lower respiratory infections are the leading infectious cause of death worldwide. We have discovered a compound that reduces the impact and disease caused by viral and bacterial infections. This study will develop the prophylactic capabilities of this agent against transmission of influenza virus A and development of secondary bacterial disease. In addition, we will identify the mechanism of action for this compound, and its utility as a broad-spectrum intervention measure against viral and bacterial infections.