Understanding the regulation of the location of chromosomes within the nucleus

每个人类细胞的细胞核，尽管直径不到10微米，但包含46条染色体，每条染色体由几厘米的DNA组成。核内染色体的组织有助于调节哪些基因被开启和关闭。附着在核膜上的核膜上的基因往往会被关闭。核层的突变会导致几种疾病，包括早衰症，从而导致过早衰老。我感兴趣的是为什么只有基因组的某些区域附着在核层上。

The nucleus of each human cell, despite being under 10µM in diameter, contains 46 chromosomes, each consisting of several centimeters of DNA. The organisation of chromosomes within the nucleus helps regulate which genes are switched on and off. Genes attached to the nuclear lamina, which lines the nuclear membrane, tend to be switched off. Mutations in the nuclear lamina cause several diseases, including progeria, resulting premature aging. I am interested in understanding why only certain regions of the genome attach to the nuclear lamina.