Understanding the role of DNMT1 SUMOylation in Acute Myeloid Leukaemia

大多数癌症都有异常高水平的DNA甲基化，这会关闭细胞死亡基因，使癌细胞不朽。我们有一种名为DNMT1i的新药，针对癌细胞的这一特征，我们最近发现了一种新的药物靶点，可以增强DNMT1i的活性。我们的研究将确定这两种药物如何协同有效地杀死癌细胞，并将证明它们在临床试验中的使用是合理的，我们相信这将改善癌症患者的预后。

Most cancers have abnormally high levels of DNA methylation, which turns off cell death genes, making cancer cells immortal. We have a new drug, called DNMT1i, that targets this feature of cancer cells and we recently found a new drug target that enhances the activity of DNMT1i. Our research will determine how these two drugs synergise to effectively kill cancer cells and will justify their use in clinical trials, which we believe will improve outcomes for patients with cancer.