Understanding the role of lipid in membrane permeabilization by the Bcl-2 family executioner proteins

细胞凋亡是一种程序性细胞死亡的形式，它保护我们的身体免受危险细胞的伤害，例如感染病毒或可能癌变的细胞。一个蛋白质家族网络控制着这一过程，这项工作将了解某些成员如何调节这一细胞死亡途径中的关键步骤。我们的研究将揭示在分子水平上对细胞凋亡的关键见解，并为以细胞死亡失调为特征的疾病（如癌症）的治疗方法的发展提供信息。

Apoptosis is a form of programmed cell death that protects our bodies from dangerous cells, e.g cells infected with viruses or that might become cancerous. A network of protein families control this process and this work will understand how certain members regulate a crucial step in this cell death pathway. Our studies will reveal key insights into apoptosis at the molecular level and inform the development of therapeutics for diseases characterised by dysregulated cell death such as cancer.