A Universal Clinical Test for Gene Fusions in Blood Cancer

断裂染色体的错误修复导致基因融合，这是血癌的共同特征。目前的测试只能检测已知的基因融合，而不能识别新的融合事件或融合变异。我们已经开发了一种名为CaptureSeq的科学技术，可以解决这些问题。我们建议将这项技术作为血癌单一临床检测的基础，能够检测所有可能的融合变异——已知的和未知的。

Mis-repair of broken chromosomes results in gene fusion and is a common feature of blood cancers. Current tests are only capable of detecting well-known gene fusions and are incapable of identifying new fusion events or fusion variations. We have developed a scientific technique, termed CaptureSeq, that can address these issues. We propose to use this technique as the foundation for a single clinical test for blood cancers, capable of detecting all possible fusion variations – known and unknown.