Upregulation of dyskerin augments telomerase enzyme activity in haematopoietic cells

癌细胞的复制是不受限制的--它们是不朽的。在90%的人类癌症中，端粒酶的激活促进了永生。相反，端粒酶缺乏症会导致危及生命的血液疾病。我们将研究端粒酶的一种蛋白质成分如何调节正常和白血病血细胞中的酶活性。这一结果将对寻求阻止癌细胞复制和治疗严重血液疾病的新方法具有价值。

The replication of cancer cells is unrestricted - they are immortal. Activation of the enzyme telomerase promotes immortalisation in 90% of human cancers. Conversely, telomerase deficiency causes life threatening blood disorders. We will investigate how one of the protein components of telomerase regulates enzyme activity in normal and leukaemic blood cells. The results will be valuable in the pursuit of new approaches to halting cancer cell replication and treating severe blood disorders.