Using exercise to target the epigenome of the ageing skeletal muscle

身体活动促进健康老龄化，但其潜在机制仍不清楚。在这个项目中，我假设体育活动通过表观遗传机制减缓衰老过程，一些人有一个遗传背景，使他们从体育活动中获得更多的好处。我将使用从Gene SMART研究中收集的数据来测试这些假设，并在遗传学，表观遗传学，运动和衰老领域的领导者的帮助下。

Physical activity promotes healthy ageing, but the underlying mechanisms are still unknown. In this project, I hypothesise that physical activity slows down the ageing process via epigenetic mechanisms and some individuals have a genetic background that predisposes them to reap more benefit from physical activity. I will use data collected from the Gene SMART study to test those hypotheses, with the help of leaders in the fields of genetics, epigenetics, exercise and ageing.