The utility of genomics and functional imaging to predict Irinotecan and Sunitinib pharmacokinetics and pharmacodynamics

癌症患者的肝脏分解抗癌药物的方式存在很大差异，这导致肿瘤反应不佳或产生严重的副作用。该项目将使用两种可能导致严重副作用的抗癌药物。患者将接受特殊的肝脏x光检查，以检查肝功能，并抽血检查对药物分解和作用重要的DNA或基因。这些基因和成像可以帮助识别有严重毒性或不良反应风险的患者，并优化药物使用。

Cancer patients have large differences in the way their liver breaks down anticancer drugs, leading to a poor tumor response or severe side effects. This project will be with 2 cancer drugs which can cause severe side effects. Patients will have special liver Xrays to check their liver function and have blood taken to look at DNA or genes important in drug breakdown and action. These genes and imaging may help identify patients at risk of severe toxicity or poor response and optimise drug use.