Vascular changes are a key contributor to and novel drug target for interferon-alpha induced neurological disease

I型干扰素（IFN-Is）有助于广泛的神经系统疾病，包括衰老和神经变性。在极端情况下，ifn - i介导的神经退行性变被称为“干扰素病”。IFN-Is驱动疾病的机制尚不清楚，这使得因果治疗变得困难。我们最近发现了突破性的证据，表明血管异常是导致这种疾病的关键因素。在这里，我们将研究干扰素病变患者的新治疗靶点。

Type I interferons (IFN-Is) contribute to wide range of neurological diseases including ageing and neurodegeneration. At its extreme IFN-I-mediated neurodegeneration is known as 'interferonopathy'. The mechanisms of how IFN-Is drive disease are unclear, making causal treatment difficult. We have recently uncovered ground-breaking evidence that abnormal blood vessels are a key contributor to the disease. Here, we will investigate novel treatment targets for patients with interferonopathies.