In vivo regulation of the Alzheimers disease beta-secretase, BACE1

痴呆症声称每周1000澳大利亚人。阿尔茨海默病（AD）是痴呆症的主要原因。AD的标志是脑中β-淀粉样蛋白（Ab）斑块的存在。Ab的积累导致毒性和细胞死亡。我们将使用尖端技术来降低产生抗体的酶（BACE 1）的水平。本研究将为进一步研究抗体的体内调控提供重要的信息，并为降低人脑中BACE 1和抗体的最终目标奠定基础。

Dementia claims 1000 Australians weekly. Alzheimer's disease (AD) is the leading cause of dementia. A hallmark of AD is the presence of beta-amyloid (Ab) plaques in brain. Accumulation of Ab leads to toxicity and cell death. We will use cutting-edge technologies to reduce the level of an enzyme (BACE1) that generates Ab. This study will provide seminal information relating to in vivo regulation of Ab and establish a foundation for our ultimate goal of decreasing BACE1 and Ab in human brain.