Development of Liposaccharide Peptide Conjugates for Peptide Drug Delivery.

用于多肽给药的脂多糖肽结合物的研究进展我们的目标是采用AlChemia获得专利的固相低聚糖合成技术，以开发允许在单一固相树脂上组装糖、脂和多肽单元的方法。这项合成技术将被用来产生两种模型多肽(LHRH和TRH)的脂糖结合物文库，以研究和优化广泛适用的多肽给药系统，该系统可以改善多肽的口服吸收、代谢稳定性和生物利用度。

Development of Liposaccharide Peptide Conjugates for Peptide Drug Delivery. We aim to adapt the Solid Phase Oligosaccharide Synthesis technology patented by Alchemia to develop methodologies that will allow the assembly of sugar, lipid and peptide units on a single solid phase resin. This synthetic technology will then be used to generate a library of liposaccharide conjugates of two model peptides (LHRH and TRH) to investigate and optimise a broadly applicable peptide drug delivery system which improves peptides oral absorption, metabolic stability and bioavailability.