Second messenger-activated calcium channels in liver cells

第二信使激活肝细胞中的钙通道。该项目涉及第二信使激活的钙通道，这是激素激活的钙通道家族的一部分，对所有动物细胞的功能都是必不可少的。本研究旨在阐明肝细胞内一种新的“大电导”钙通道(以蜂毒毒素为人工激活剂)、肌醇1，4，5-三磷酸激活的钙通道以及由瞬时受体电位-1(Trp-1)蛋白形成的钙通道的性质。将研究通道的电生理特性、激活机制和细胞内转运。预计结果将提供有关第二信使激活的钙通道的生理功能的基本信息。这将有助于了解动物的肝功能、肝脏毒性、动物生产以及畜牧业药物的开发。

Second messenger-activated calcium channels in liver cells. This project concerns second messenger-activated calcium channels, part of the family of hormone-activated calcium channels which are essential to the functions of all animal cells. The aims are to elucidate the properties of a novel "large conductance" Ca2+ channel (using maitotoxin as an artificial activator), an inositol 1,4,5-trisphosphate-activated calcium channel, and the calcium channel formed by the transient receptor potential-1 (TRP-1) protein in hepatocytes. The electrophysiological properties, mechanisms of activation and intracellular trafficking of the channels will be investigated. It is anticipated the results will provide basic information on the physiological functions of second messenger-activated calcium channels. This will benefit the understanding of liver function, hepatotoxicity in animals, animal production and the development of pharmaceuticals in animal husbandary.