Structure and Function of the AMP-activated protein kinase

AMP激活的蛋白激酶的结构和功能。AMP激活的蛋白激酶(AMPK)是代谢应激敏感蛋白激酶亚家族的一员，存在于所有真核生物中，包括酵母同源物、SNF1p蛋白激酶，对适应无糖生长是必不可少的。AMPK在将新陈代谢与所有生理过程的营养供应和能量需求相匹配方面发挥着重要作用。这个项目的目的是了解AMPK的结构和功能。这项工作可能会为药物设计提供重要的机会，了解新陈代谢和衰老的影响，并增加我们对控制细胞事件的信号通路的知识。

Structure and Function of the AMP-activated protein kinase. The AMP-activated protein kinase (AMPK) is a member of the metabolic stress sensing protein kinase subfamily that is present in all eukaryotes, including the yeast homologue, snf1p protein kinase essential for adapting to growth without glucose. The AMPK plays an important role in matching metabolism to nutrient supply and energy demand of perhaps all physiological processes. The aim of this project is to understand the structure and function of the AMPK. This work may provide important opportunities for drug design, understanding the impact of metabolism and ageing as well as increasing our knowledge of signalling pathways that control cellular events.