The Chemistry and Biochemistry of Chromium: Cancer and Nutrition

铬的化学与生物化学：癌症与营养。在所有人类致癌物中，铬（VI）的职业暴露水平最高，并且作为一种环境致癌物越来越受到关注，正如电影《永不永不》所强调的那样。同样，人类和动物对铬（III）营养补充品的消耗量也在迅速上升，尽管人们越来越担心其致癌风险。然而，铬生物化学的复杂性是这样的，它仍然知之甚少。本项目旨在为Cr生物化学提供新的见解，这些见解与评估职业和环境暴露的风险因素以及生产更安全的Cr膳食补充剂有关。

The Chemistry and Biochemistry of Chromium: Cancer and Nutrition. Of all of the human carcinogens, chromium(VI) has the highest level of occupational exposure, and is of increasing concern as an environmental carcinogen, as highlighted by the film Erin Brockovitch. Similarly, chromium(III) nutritional supplement consumption by humans and animals is rising rapidly, despite mounting concerns about their cancer risks. However, the complexity of Cr biochemistry is such that it is still poorly understood. This project aims at providing new insights into Cr biochemistry that are of relevance in evaluating risk factors for occupational and environmental exposure and for producing safer Cr dietary supplements.