Nutrient-endocrine interactions and muscle mitochondrial health with fatty acid oversupply

肥胖极大地增加了罹患2型糖尿病和心血管疾病的风险，而心血管疾病是加拿大成年人的头号杀手。根据目前的估计，超过680万加拿大成年人肥胖，使其成为可预防的死亡的主要原因之一。这项研究建议的主要假设是，糖尿病前期患者的肌肉过度产生肌肉抑制素，这是一种调节肌肉大小和功能的循环蛋白，可能有助于疾病的进展。我们的第二个假设是，高水平的循环脂肪会损害肌肉线粒体，这是细胞的动力源。这两个发现都很重要，因为随着肥胖症发展为完全的2型糖尿病，肌肉功能普遍下降。这项研究提案中描述的实验将有助于确定

Obesity dramatically increases the risk for developing type 2 diabetes and cardiovascular disease, the number 1 killer of adults in Canada. According to current estimates over 6.8 million adult Canadians are obese placing it among the leadingcauses of preventable death. The primary hypothesis of this research proposal is that muscle of pre-diabetic individuals overproduces myostatin, a circulating protein that regulates muscle size and function and may contribute to disease progression. Our secondary hypothesis is that high levels of circulating fat damages muscle mitochondria, the cellular powerhouses. These finding are both important because there is a general decline in muscle function with the progression ofobesity to full-blown type 2 diabetes. The experiments described in this research proposal will help determine the role of