Kinin B1 receptor as a key target in the treatment of hypertension and insulin resistance
Kinin B1 receptor as a key target in the treatment of hypertension and insulin resistance
批准号:
238159
负责人:
Couture Rjean
金额:
$46.69万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2011
资助国家:
加拿大
项目状态:
已结题
起止时间:
2011-09-01 至 2016-09-01
中文摘要
我们发现,抗氧化剂或B1受体(B1R)抑制剂对激肽(局部激素和脑介质)
逆转大鼠模型中的高血压和糖尿病异常。B1R在健康受试者中缺乏,其发生是由于
英文摘要
We showed that treatments with antioxidants or inhibitors of B1 receptor (B1R) for kinins (local hormone and brain mediator)
reversed hypertension and diabetes abnormalities in rat models. The B1R is absent in healthy subjects and its occurrence is the si
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