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The Potential of the Human Proton Coupled Folate Transporter as a Novel Approach for Therapeutic Targeting of Solid Tumors

The Potential of the Human Proton Coupled Folate Transporter as a Novel Approach for Therapeutic Targeting of Solid Tumors
人类质子耦合叶酸转运蛋白作为实体瘤治疗靶向新方法的潜力
批准号：
174628
负责人：
Kugel Sita
金额：
$5.9万
依托单位：
Wayne State University (Michigan)
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2008
资助国家：
加拿大
项目状态：
已结题
起止时间：
2008-10-01 至 2011-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=174628&lang=en
关键词：
Antifolates Chemotherapy Drug Discovery Folate Membrane Transport Microenvironment Proton Coupled Folate Transporter Solid Tumors Tumor Targeting

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中文摘要
翻译
叶酸是B族维生素，由于其在DNA合成中的作用，对生命至关重要。癌细胞以不受控制的方式增殖，并且高度依赖于DNA合成。抗叶酸剂是叶酸类似物，其抑制癌细胞的能力，
英文摘要
Folates are B vitamins and are essential for life because of their role in DNA synthesis. A cancer cell proliferates in an uncontrolled manner and is highly dependent on DNA synthesis. Antifolates are folate analogs that inhibit the ability of cancer cell
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