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Characterization of V-ATPase subunit isoforms as therapeutic targets for diverse diseases including bone loss in inflammatory arthritis

Characterization of V-ATPase subunit isoforms as therapeutic targets for diverse diseases including bone loss in inflammatory arthritis
V-ATP酶亚基亚型作为多种疾病(包括炎症性关节炎中骨质流失)治疗靶点的表征
批准号:
254898
负责人:
Manolson Morris F
金额:
$42.21万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-03-01 至 2017-03-01

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中文摘要
翻译
体内许多基本的“家务管理”功能都需要将酸输送到细胞和组织的细胞膜上。酸被泵入溶酶体中,溶酶体是细胞的回收箱,它将旧的细胞成分分解成可重复使用的积木
英文摘要
Many essential 'housekeeping' functions in the body require acid to be pumped across the membranes of cells and tissues. Acid is pumped into lysosomes, cellular recycling bins that break down old cell components into reusable building blocks, and it is pu
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会议论文
Elucidating the role of the V-ATPase "a" subunit in targeting and function: a novel therapeutic target for bone-loss pathologies and cancer
  • 批准号:
    344253
  • 项目类别:
    Operating Grants
  • 资助金额:
    $31.47万
  • 财政年份:
    2016
  • 负责人:
    Manolson Morris F
  • 依托单位:
Characterizing mutations in the a3 V-ATPase subunit in osteoclasts: A key player in bone loss due to inflammatory arthritis
  • 批准号:
    210556
  • 项目类别:
    Operating Grants
  • 资助金额:
    $44.59万
  • 财政年份:
    2010
  • 负责人:
    Manolson Morris F
  • 依托单位:
国内基金
海外基金
Autoimmune diseases therapies: variations on the microbiome in rheumatoid arthritis
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data