Translational Control of Apolipoprotein B mRNA

我们建议研究在脂质代谢中重要的蛋白质的生物化学和细胞生物学。人的肝脏分泌许多被称为“载脂蛋白”的蛋白质，这些蛋白质对形成被称为“脂蛋白”的脂质颗粒至关重要。人体肝脏分泌和代谢脂蛋白对维持血浆中脂肪和胆固醇的水平非常重要。我们对调节这些蛋白质合成和分泌的基本分子和细胞机制感兴趣。在过去的几年里，我们的实验室一直在研究这些机制，并在载脂蛋白B合成的调节方面取得了一些重要的观察结果。我们现在建议继续这些研究，以进一步阐明关键的翻译控制机制。

We are proposing to study the biochemistry and cell biology of proteins important in lipid metabolism. Human liver secretes a number of proteins called "apolipoproteins" which are essential for formation of lipid particles called "lipoproteins". Secretion and metabolism of lipoproteins by the human liver is very important in maintaining the plasma levels of fat and cholesterol. We are interested in the basic molecular and cellular mechanisms which regulate the synthesis and secretion of these proteins. Our laboratory has been studying these mechanisms for the past several years and has made a number of important observations on regulation of apolipoprotein B synthesis. We now propose to continue these investigations to further elucidate key translational control mechanisms.