Mechanisms of microbial copper and iron homeostasis
Mechanisms of microbial copper and iron homeostasis
批准号:
194212-2010
负责人:
Murphy, Michael
金额:
$4.81万
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-01-01 至 2014-12-31
中文摘要
过渡金属对生命是必不可少的,因为它们是细胞维持反应所需的辅因子,例如细胞色素氧化酶或构成DNA的核糖核苷酸还原酶利用氧作为末端电子受体。铜和铁等金属的这种特殊的反应性需要严格控制细胞的摄取和处理,以避免毒副作用。了解微生物体内铜和铁的动态平衡机制是本研究计划的主要方向。在这项提议中,正在研究的系统是来自羽状硅藻的铁储存蛋白铁蛋白,以及使用细菌中的铜辅助因子进行铁运输的两个系统。
英文摘要
Transition metals are essential for life as they are required cofactors for cell sustaining reactions such as the use of oxygen as a terminal electron acceptor by cytochrome oxidase or by ribonucleotide reductases that make the building blocks of DNA. This special reactivity of metals such as copper and iron necessitate tight control of uptake and handling by the cell to avoid toxic side effects. Understanding the mechanisms of this copper and iron homeostasis in microbes is main direction of this research program. In this proposal, systems under investigation are the iron storage protein ferritin from a pennate diatom and two systems of iron transport using a copper cofactor in bacteria.
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会议论文
Bacterial iron acquisition
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批准号:RGPIN-2022-04568
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.91万
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财政年份:2022
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负责人:Murphy, Michael
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依托单位:
Illuminating the dark metabolome via deep learning and probabilistic graphical models
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批准号:544268-2020
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项目类别:Postgraduate Scholarships - Doctoral
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资助金额:$1.53万
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财政年份:2021
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负责人:Murphy, Michael
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依托单位:
Iron Storage by Ferritin and Microbial Growth
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批准号:RGPIN-2015-04802
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2021
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负责人:Murphy, Michael
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依托单位:
Iron Storage by Ferritin and Microbial Growth
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批准号:RGPIN-2015-04802
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2020
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负责人:Murphy, Michael
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依托单位:
Illuminating the dark metabolome via deep learning and probabilistic graphical models
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批准号:544268-2020
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项目类别:Postgraduate Scholarships - Doctoral
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资助金额:$1.53万
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财政年份:2020
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负责人:Murphy, Michael
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依托单位:
Iron Storage by Ferritin and Microbial Growth
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批准号:RGPIN-2015-04802
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2019
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负责人:Murphy, Michael
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依托单位:
Iron Storage by Ferritin and Microbial Growth
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批准号:RGPIN-2015-04802
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2018
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负责人:Murphy, Michael
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依托单位:
Iron Storage by Ferritin and Microbial Growth
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批准号:RGPIN-2015-04802
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2017
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负责人:Murphy, Michael
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依托单位:
Iron Storage by Ferritin and Microbial Growth
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批准号:477778-2015
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项目类别:Discovery Grants Program - Accelerator Supplements
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资助金额:$2.91万
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财政年份:2017
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负责人:Murphy, Michael
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依托单位:
Water quality changes in Mississippi Lake, eastern Ontario
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批准号:512895-2017
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项目类别:University Undergraduate Student Research Awards
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资助金额:$0.33万
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财政年份:2017
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负责人:Murphy, Michael
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依托单位:
Iron Storage by Ferritin and Microbial Growth
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批准号:477778-2015
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项目类别:Discovery Grants Program - Accelerator Supplements
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资助金额:$2.91万
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财政年份:2016
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负责人:Murphy, Michael
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依托单位:
Iron Storage by Ferritin and Microbial Growth
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批准号:RGPIN-2015-04802
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2016
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负责人:Murphy, Michael
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依托单位:
Characterizing the impact of a novel therapeutic on the infection strategy of pathogens
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批准号:501378-2016
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项目类别:Engage Plus Grants Program
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资助金额:$0.91万
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财政年份:2016
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负责人:Murphy, Michael
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依托单位:
Iron Storage by Ferritin and Microbial Growth
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批准号:RGPIN-2015-04802
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2015
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负责人:Murphy, Michael
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依托单位:
Characterizing the impact of a novel therapeutic on the infection strategy of pathogens
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批准号:491902-2015
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项目类别:Engage Grants Program
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资助金额:$1.82万
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财政年份:2015
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负责人:Murphy, Michael
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依托单位:
Iron Storage by Ferritin and Microbial Growth
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批准号:477778-2015
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项目类别:Discovery Grants Program - Accelerator Supplements
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资助金额:$2.91万
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财政年份:2015
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负责人:Murphy, Michael
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依托单位:
Mechanisms of microbial copper and iron homeostasis
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批准号:194212-2010
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.81万
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财政年份:2014
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负责人:Murphy, Michael
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依托单位:
Analysing Macromolecular Binding at Biological Surfaces by Surface Plasmon Resonance
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批准号:458782-2014
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项目类别:Research Tools and Instruments - Category 1 (<$150,000)
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资助金额:$10.93万
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财政年份:2013
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负责人:Murphy, Michael
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依托单位:
Thymidylate kinase as a target for therapeutics to counter gram-negative bacterial infection
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批准号:452482-2013
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项目类别:Engage Grants Program
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资助金额:$1.82万
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财政年份:2013
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负责人:Murphy, Michael
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依托单位:
Mechanisms of microbial copper and iron homeostasis
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批准号:194212-2010
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.81万
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财政年份:2012
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负责人:Murphy, Michael
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依托单位:
国内基金
海外基金
碳-铁-微生物对滩涂围垦稻田土壤团聚体形成和稳定的调控机制
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批准号:41977088
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项目类别:面上项目
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资助金额:61.0万元
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批准年份:2019
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负责人:刘亚龙
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依托单位:
水热炭的微生物陈化(Microbial-aged Hydrochar)及其对稻田氨挥发的影响机制
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批准号:41877090
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项目类别:面上项目
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资助金额:61.0万元
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批准年份:2018
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负责人:冯彦房
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依托单位:
微生物发酵过程的自组织建模与优化控制
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批准号:60704036
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项目类别:青年科学基金项目
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资助金额:21.0万元
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批准年份:2007
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负责人:高学金
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依托单位: