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Establishment of Long-Lived HIV-1 Reservoirs in Naive Th17 Precursors: Implications for the Cure

Establishment of Long-Lived HIV-1 Reservoirs in Naive Th17 Precursors: Implications for the Cure
在幼稚 Th17 前体中建立长寿命 HIV-1 储库：对治疗的影响
批准号：
276953
负责人：
Ancuta Petronela
金额：
$7.29万
依托单位：
Centre hospitalier de l'Universit de Montral (CHUM)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-11-01 至 2013-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=276953&lang=en
关键词：
Antiretroviral Therapy Central Memory Cd4+ T-Cells Confocal Microscopy Fluorescence In Situ Hybridization (Fish) Hiv-1 Reservoirs Multicolor Flow Cytometry Naive Cd4+ T-Cells Real Time Pcr Slow Progressors Th17 Cells

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中文摘要
翻译
在罕见的长寿记忆性CD 4 + T细胞亚群中潜伏的HIV-1储库的持续存在代表了在病毒抑制性抗逆转录病毒疗法时代根除的一个主要障碍。目前正在研究不同的方法来重新激活艾滋病毒
英文摘要
Persistence of latent HIV-1 reservoirs in rare subsets of long lived memory CD4+ T-cells represents one major barrier to eradication in the era of viral suppressive antiretroviral therapy. Different approaches are now under investigation to reactivate HIV
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