Identification of the cell surface receptor for the aleutian disease parvovirus

在加拿大，水貂养殖是一个价值数百万美元的产业，大部分貂皮出口到世界各地的买家。加拿大貂皮因其高品质而享誉国际。一般来说，水貂工业集中在其他农业活动受到土壤和/或气候限制的地区。这一点在新斯科舍省尤为明显，该省生产了加拿大大约一半的水貂皮，该行业对鱼类和其他动物副产品的使用有助于当地经济，而不会对现有资源造成压力。目前，加拿大和全世界水貂业面临的主要疾病威胁是阿留申病病毒，尽管实施了广泛而昂贵的监测计划，但该病毒仍在继续影响水貂养殖场。本研究的目的是鉴定阿留申病病毒用来进入水貂易感细胞的受体蛋白。病毒受体蛋白的鉴定旨在提供新的基础信息，作为长期解决阿留申病问题的基础。

Mink ranching is a multi-million dollar industry in Canada with the bulk of the pelts exported to buyers worldwide. Canadian mink pelts are prized internationally for their premium quality. The mink industry, in general, is concentrated in areas where other agricultural activities are impeded by soil and/or climatic constraints. This is particularly true of Nova Scotia, which produces approximately one half of Canada's mink pelts, and where the industry's use of fish and other animal by-products helps the local economy without putting pressure on the available resources. The primary disease threat to the mink industry in Canada and worldwide, at this time, is the Aleutian disease virus which continues to impact mink ranching despite an extensive, costly monitoring program. The objective of this study is the identification of the receptor protein that the Aleutian disease virus uses to enter susceptible cells in the mink. Identification of the viral receptor protein is intended to provide new fundamental information to serve as the basis for a long term solution to the Aleutian disease problem.