RNA Interfering Nanoparticles against Human Papillomavirus Variants

人乳头瘤病毒(HPV)是一种有200多种类型的DNA病毒家族，非常特异地感染皮肤、生殖器、上呼吸道和胃肠道的上皮细胞。这种病毒是人类最常见的感染之一，我们几乎所有人都在生活中的某个时候感染了这种病毒。大约20种类型的HPV可以导致上皮细胞的恶性转化，如果持续足够长的时间，可能会导致宿主的恶性肿瘤。HPV16是转化类型中最常见的，但有趣的是，只有一小部分宿主(估计为1%或更少)会发展为恶性肿瘤。这些肿瘤约占人类所有恶性肿瘤的15%。Zehbe博士假设，HPV变种在HPV感染细胞的恶变过程中发挥了作用。

Human papillomavirus (HPV) is a DNA virus family of more than 200 types that very specifically infect epithelial cells of the skin, genital, upper-respiratory and -gastrointestinal tract. This virus is one the most common infections in humans and virtually all of us are infected at some point in our lives. Approximately 20 HPV types can cause malignant transformation of epithelial cells and, if persistent long enough, can cause malignant tumours in their hosts. HPV 16 is the most common amongst the transforming types but intriguingly, only a subset of hosts (estimated to be 1% or less), develop a malignant tumour. These tumours account for approximately 15% of all malignancies in humans. Dr. Zehbe hypothesized that HPV variants play a role in malignant transformation of HPV-infected cells.