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Hepatic Bile Acid and Organic Anion Transporting Polypeptide (OATP) drug uptake transporters as determinants of drug disposition

Hepatic Bile Acid and Organic Anion Transporting Polypeptide (OATP) drug uptake transporters as determinants of drug disposition
肝胆汁酸和有机阴离子转运多肽（OATP）药物摄取转运蛋白作为药物处置的决定因素
批准号：
280071
负责人：
Kim Richard B
金额：
$53.73万
依托单位：
University of Western Ontario
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2013
资助国家：
加拿大
项目状态：
已结题
起止时间：
2013-03-01 至 2018-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=280071&lang=en
关键词：
Clinical Pharmacology Drug Disposition Drug Transporters Liver Transporters Pharmacogenetics

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中文摘要
翻译
众所周知，肝脏是一种器官，能够分解(代谢)我们摄入的外来化学物质和药物，然后将这些分解产物分泌到胆汁中，随后被排除在体内。具体地说，我们现在知道这些细胞
英文摘要
Liver is widely known as an organ capable of breaking down (metabolism) foreign chemicals and drugs that we ingest, and then secrete such breakdown products into bile for subsequent elimination out of the body. Specifically, we now know that the cells tha
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会议论文
Organic Anion Transporting Polypeptide (OATP), P-glycoprotein (P-gp), and Breast Cancer Resistance Protein (BCRP) transporters modulate tamoxifen response during breast cancer therapy
  • 批准号：
    452037
  • 项目类别：
    Operating Grants
  • 资助金额：
    $47.93万
  • 财政年份：
    2021
  • 负责人：
    Kim Richard B
  • 依托单位：
    University of Western Ontario
Integrated Precision Medicine Technology and Approach for Optimal Drug Therapy for Canadians
Clinical and pharmacogenomic predictors of inter-patient variation in direct acting oral anticoagulant (DOAC) plasma concentrations in real-world patients
  • 批准号：
    338124
  • 项目类别：
    Miscellaneous Programs
  • 资助金额：
    $36.24万
  • 财政年份：
    2015
  • 负责人：
    Kim Richard B
  • 依托单位：
    University of Western Ontario
Best Brains Exchange: ''Canada as a Leader in the Development and Deployment of Precision/Personalized Medicine'' March 23, 2015 in Ottawa, ON.
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