A Facility for Environmentally-controlled Live-Cell Imaging

荧光显微镜和绿色荧光蛋白(GFP)等基因编码荧光蛋白的发现使研究人员能够观察活细胞中的分子和亚细胞结构，从而使获得细胞和分子过程的时空信息成为可能，从而使细胞生物学发生了革命性的变化。重要的是，荧光显微镜是研究支撑疾病和疾病进展的分子机制的强大工具，反过来，这可能为如何治疗困扰加拿大人的疾病提供线索。总的来说，我们的研究计划旨在了解驱动i)细胞器(细胞的器官)是如何形成和发挥功能的分子机制，ii)膜和蛋白质是如何在细胞内调节和运输的，iii)病原体如何相互作用和篡夺它们的哺乳动物宿主细胞，以及iv)超声波的生物医学应用。

Fluorescence microscopy, and the discovery of genetically encoded fluorescent proteins like Green Fluorescent Protein (GFP), revolutionized cell biology by permitting researchers to observe molecules and sub-cellular structures in living cells, thus making it possible to obtain spatial and temporal information of cellular and molecular processes. Importantly, fluorescence microscopy is a powerful tool to study the molecular mechanisms that underpin diseases and disease progression and, in turn, this may provide clues on how to treat diseases that afflict Canadians. Collectively, our research programs aim to understand the molecular mechanisms driving i) how organelles, which are the "organs of the cell", are made and function, ii) how membrane and proteins are regulated and transported within cells, iii) how pathogens interact and usurp their mammalian host cells and iv) the biomedical applications of ultrasound.