Why certain viruses don't get along in mosquitoes. The molecular mechanism.

该项目的总体目标是了解某些纯昆虫病毒是如何使蚊子无法传播疾病的。这些病毒被称为昆虫特有的黄病毒，可用作蚊媒传播的人类和兽医疾病的生防剂。然而，由于目前还不清楚它们到底是如何影响蚊子的，使用它们的安全性和有效性也无法预测。拟议的项目将剖析昆虫特有的黄病毒和蚊子之间非常复杂的相互作用机制，并解释它们是如何确切地防止疾病传播的。它应该产生新的基础知识，实施创新的方法，并为学生和初级科学家提供培训。

The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The proposed project will dissect the very intricate mechanisms of interactions between insect-specific flaviviruses and mosquitoes and explain how exactly they prevent disease transmission. It should generate novel fundamental knowledge, implement innovative methodologies and provide training for students and junior scientist.