Canada Research Chair in Emerging Organic Materials

本研究计划的长期重点是识别和表征参与动物正常生理功能的离子转运系统。离子和酸碱状态的调节对于正常的细胞功能和代谢是绝对必要的，也是适应不同环境的一个组成部分。此外，离子和酸碱代谢紊乱与许多动物病理有关。了解这些离子和酸碱转运系统进化的分子机制和调控将使我们能够理解和预测对环境变化（pH、盐度、温度的变化）或各种环境应激源（如毒物（如水性金属、污染物、有机物））的生理适应性。我使用各种模型系统来研究这些过程，并检查离子和酸碱转运体的调节和控制。我的研究项目使用淡水动物（鱼、蟹、蚊子）和海水动物（角鲨、盲鳗、螃蟹、海绵），通过在阿尔伯塔省和班菲尔德海洋科学中心进行的研究。研究计划的总体目标是了解离子和酸碱运输及其调控的共同和独特方法。

The long-term focus of the research program is to identify and characterize ion transport systems involved in the normal functional physiology in animals. Regulation of ion and acid-base status is absolutely essential for proper cell function and metabolism and is also an integral component of adaptability to different environments. Furthermore, disorders of ion and acid-base metabolism are linked to numerous animal pathologies. Understanding the molecular mechanisms and regulation of these ion and acid-base transport system evolution will enable us to understand and predict physiological adaptability to environmental change (changes in pH, salinity, temperature) or various environmental stressors such as toxicants (e.g. waterborne metals, pollutants, organic matter). I use a variety of model systems to investigate these processes and examine the regulation and control of ion and acid-base transporters. My research program uses both freshwater animals (fish, crabs, mosquitoes) and seawater animals (dogfish, hagfish, crabs, sponges) through research conducted in both Alberta and at Bamfield Marine Sciences Centre. The overarching goal of the research program is to understanding both the common and unique methods of ion and acid-base transport and its regulation.