Using genetically engineered mouse models to define variables producing pancreatic ductal adenocarcinoma heterogeneity

肿瘤异质性主要被认为是由不同的基因突变事件引起的。越来越多的证据还表明，不同的肿瘤起始细胞类型或起源细胞也可能导致前列腺癌和乳腺癌的异质性。然而

Tumor heterogeneity is largely thought to arise from different gene mutation events. Mounting evidence also suggests that distinct tumor-initiating cell types, or cells of origin, may also contribute to heterogeneity in prostate and breast cancer. However