Targeting the mevalonate pathway and its SREBP-induced feedback mechanism in prostate cancer
Targeting the mevalonate pathway and its SREBP-induced feedback mechanism in prostate cancer
批准号:
337321
负责人:
Longo Joseph
金额:
$0.07万
依托单位国家:
加拿大
项目类别:
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-10-01 至 2016-10-01
中文摘要
他汀类药物是治疗高胆固醇的常规处方,但也被证明具有抗癌特性。我们和其他人已经证明,他汀类药物可以通过抑制甲羟戊酸途径(一种关键途径)诱导肿瘤特异性细胞死亡
英文摘要
Statins are routinely prescribed for the treatment of high cholesterol, but have also been shown to possess anti-cancer properties. We, and others, have shown that statins can induce tumour-specific cell death by inhibiting the mevalonate pathway, a cruci
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依托单位:
海外基金