课题基金 / 基金详情

Understanding phytoglycan nanoparticles' ability to modulate the innate immune response

Understanding phytoglycan nanoparticles' ability to modulate the innate immune response
了解植物聚糖纳米颗粒调节先天免疫反应的能力
批准号:
490968-2015
负责人:
DeWitteOrr, Stephanie
金额:
$0.91万
依托单位:
依托单位国家:
加拿大
项目类别:
Engage Plus Grants Program
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-01-01 至 2016-12-31

项目摘要

项目成果

DeWitteOrr, Stephanie的其他基金

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中文摘要
翻译
先天免疫系统是抵御入侵的致病生物体的第一道防线,在感染后立即采取行动保护动物。它也是一个重要的调节因子,影响疫苗的效力、自身免疫和炎症反应。我们正在寻求植球蛋白(PHX)的新用途,这是一种基于糖原的纳米颗粒,是天然的、可生物降解的、无毒的,而且很容易修饰。目前的NSERC Engage Plus将资助研究,以调查PHX在控制包括鱼类和人类细胞在内的动物的先天性免疫反应中的作用。这项工作对开发新的抗病毒疗法、疫苗佐剂和抗炎药物具有长期意义。
英文摘要
The innate immune system is the first line of defense against invading disease-causing organisms, acting to protect animals immediately following infection. It is also an important regulator, which influences vaccine efficacy, autoimmunity, and inflammatory responses. We are pursuing novel uses for Phytospherix (PHX), a glycogen-based nanoparticle that is natural, biodegradable, non-toxic and easily modifiable. The current NSERC Engage Plus will fund research to investigate the role of PHX in controlling innate immune responses in animals, including fish and human cells. This work has long-term implications for developing novel antiviral therapies, vaccine adjuvants and anti-inflammatory drugs.
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  • 项目类别:
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