Novel functions of importin-alpha in RNA metabolism and the stress response
Novel functions of importin-alpha in RNA metabolism and the stress response
批准号:
RGPIN-2015-04137
负责人:
Stochaj, Ursula
金额:
$2.77万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-01-01 至 2016-12-31
中文摘要
在真核细胞中,Importin-a蛋白家族(这里称为Importin-a)在细胞生理的多个方面起着重要作用。除了核运输,家庭成员还牵涉到其他重要的生物过程。最近的研究表明,Importin-a在RNA代谢和应激反应中具有新的功能。因此,我们证明了Importin-A1与Poly(A)-RNA结合。我们还发现,Importin-a家族的多个成员与细胞质应激颗粒(SGS)相关。Importin-a蛋白如何对这些关键的细胞活动做出贡献还不是很清楚。我们的研究计划将解决这些核心的生物学问题。
英文摘要
In eukaryotic cells, the importin-a protein family (here referred to as importin-a) contributes to multiple aspects of cell physiology. Aside from nuclear transport, family members are implicated in additional vital biological processes. Recent studies suggest that importin-a has new functions in RNA metabolism and the stress response. Thus, we demonstrated that importin-a1 binds poly(A)-RNA. We also showed that multiple members of the importin-a family associate with cytoplasmic stress granules (SGs). How importin-a proteins contribute to these crucial cellular activities is not well understood. Our research program will address these central biological questions.
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会议论文
Novel functions of nuclear transport factors in cellular homeostasis
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批准号:RGPIN-2020-05104
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.33万
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财政年份:2022
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负责人:Stochaj, Ursula
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依托单位:
Novel functions of nuclear transport factors in cellular homeostasis
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批准号:RGPIN-2020-05104
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.33万
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财政年份:2021
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负责人:Stochaj, Ursula
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依托单位:
Novel functions of nuclear transport factors in cellular homeostasis
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批准号:RGPIN-2020-05104
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.33万
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财政年份:2020
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负责人:Stochaj, Ursula
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依托单位:
Novel functions of importin-alpha in RNA metabolism and the stress response
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批准号:RGPIN-2015-04137
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.77万
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财政年份:2019
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负责人:Stochaj, Ursula
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依托单位:
Novel functions of importin-alpha in RNA metabolism and the stress response
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批准号:RGPIN-2015-04137
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.77万
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财政年份:2018
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负责人:Stochaj, Ursula
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依托单位:
Novel functions of importin-alpha in RNA metabolism and the stress response
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批准号:RGPIN-2015-04137
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.77万
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财政年份:2017
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负责人:Stochaj, Ursula
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依托单位:
Novel functions of importin-alpha in RNA metabolism and the stress response
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批准号:RGPIN-2015-04137
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.77万
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财政年份:2016
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负责人:Stochaj, Ursula
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依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
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批准号:155509-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.35万
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财政年份:2013
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负责人:Stochaj, Ursula
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依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
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批准号:155509-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.35万
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财政年份:2012
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负责人:Stochaj, Ursula
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依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
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批准号:155509-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.35万
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财政年份:2011
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负责人:Stochaj, Ursula
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依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
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批准号:155509-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.35万
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财政年份:2010
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负责人:Stochaj, Ursula
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依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
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批准号:155509-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.35万
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财政年份:2009
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负责人:Stochaj, Ursula
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依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
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批准号:155509-2007
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项目类别:Discovery Grants Program - Group
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资助金额:$1.82万
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财政年份:2008
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负责人:Stochaj, Ursula
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依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
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批准号:155509-2007
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项目类别:Discovery Grants Program - Group
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资助金额:$1.82万
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财政年份:2007
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负责人:Stochaj, Ursula
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依托单位:
Functional analysis of nucleoporins
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批准号:155509-2000
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.26万
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财政年份:2003
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负责人:Stochaj, Ursula
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依托单位:
Functional analysis of nucleoporins
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批准号:155509-2000
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.26万
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财政年份:2002
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负责人:Stochaj, Ursula
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依托单位:
Functional analysis of nucleoporins
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批准号:155509-2000
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.26万
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财政年份:2001
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负责人:Stochaj, Ursula
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依托单位:
Functional analysis of nucleoporins
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批准号:155509-2000
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.26万
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财政年份:2000
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负责人:Stochaj, Ursula
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依托单位:
Protein traffic in growing mammalian cells
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批准号:155509-1996
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.27万
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财政年份:1999
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负责人:Stochaj, Ursula
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依托单位:
Protein traffic in growing mammalian cells
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批准号:155509-1996
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.16万
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财政年份:1998
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负责人:Stochaj, Ursula
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依托单位:
国内基金
海外基金
数学物理中精确可解模型的代数方法
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批准号:11771015
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项目类别:面上项目
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资助金额:48.0万元
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批准年份:2017
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负责人:Oleksiy Zhedanov
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依托单位: