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Molecular characterization of a breast cancer biopsy series at single cell resolution to characterize adaptive, intrinsic, and mutational resistance to chemotherapy

Molecular characterization of a breast cancer biopsy series at single cell resolution to characterize adaptive, intrinsic, and mutational resistance to chemotherapy
以单细胞分辨率对乳腺癌活检系列进行分子表征，以表征对化疗的适应性、内在性和突变耐药性
批准号：
350079
负责人：
Laks Emma
金额：
$1.27万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2015
资助国家：
加拿大
项目状态：
已结题
起止时间：
2015-12-01 至 2016-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=350079&lang=en
关键词：
Breast Cancer Chemotherapy Clonal Dynamics Drug Resistance Drug Selection Single Cell Genomics Single Cell Transcriptomics Tumour Heterogeneity Tumour Microenvironment Xenograft Mice

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中文摘要
翻译
乳腺癌是一种高度致命的疾病，在遗传水平和突变基因的表达上，患者之间和患者内部都有很高的可变性。表征这些变异的传统方法通常是观察整个肿瘤
英文摘要
Breast cancer is a highly deadly disease with a high level of variability between and within patients, both on the genetic level and in the expression of mutant genes. Traditional methods to characterize these variations typically look at an entire tumour
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