Identification and characterization of interactome of glucagon receptor subfamily

胰高血糖素亚家族受体（Glucagon-subfamily receptor，GSR）属于最大的哺乳动物G蛋白偶联受体（GPCR）家族。最值得注意的是，胰高血糖素样肽1受体（GLP 1 R）、胰高血糖素样肽-2（GLP 2 R）受体和胰高血糖素受体（GcgR）对于维持动物的血糖水平是重要的。与GLP 1 R结合并激活GLP 1 R的激素GLP 1负责葡萄糖刺激胰腺胰岛素产生细胞分泌胰岛素以降低血糖。相比之下，胰高血糖素的主要作用是通过其受体（GcgR）在肝脏中起作用，以增加葡萄糖的产生，从而缓解或防止血糖过低。GLP 2主要存在于肠细胞中，并调节糖吸收到血液中的其他功能。与许多其他GPCR一样，这些GSR的激活是通过辅助/相互作用蛋白介导的，然而对于大多数受体，这些仍然是未知和未发现的。

The Glucagon-subfamily receptors (GSRs) belong to the largest mammalian receptor family of G-protein coupled receptors (GPCRs). Most notably, the glucagon-like peptide 1 receptor (GLP1R), the Glucagon-like peptide-2 (GLP2R) receptor and the glucagon receptor (GcgR) are important for maintaining blood sugar levels in animals. The hormone GLP1, which binds to and activates the GLP1R, is responsible for glucose stimulated insulin secretion from pancreatic insulin producing cells to reduce blood sugar. In contrast, the major action of glucagon is to act through its receptor (GcgR) in the liver to increase glucose production to alleviate or prevent blood sugar from falling too low. GLP2 is found in mainly in intestinal cells and regulates among other things sugar absorption into the bloodstream. The activation of these GSRs like many other GPCRs, is mediated through accessory/interacting proteins, however for most receptors, these remain unknown and undiscovered.