Endogenous Retroelements and the Evolution of Vertebrate Transcription Factors

内源性逆转录元件（ERE）是通过转录成RNA然后再转录回DNA而在整个基因组中复制自身的遗传元件。 大多数脊椎动物基因组包含数百种ERE的残留物，这些ERE已经积累了数百万年，通常每种ERE都有数千个拷贝分散在整个基因组中。 ERE是形成新的DNA调控区的主要贡献者，因为它们携带转录因子（TF）的结合位点。

Endogenous retroelements (EREs) are genetic elements that replicate themselves throughout the genome by transcription to RNA and then back to DNA.  Most vertebrate genomes contain remnants of hundreds types of EREs that have accumulated over millions of years, often with thousands of copies of each scattered throughout the genome.  EREs are a major contributor to the formation of new DNA regulatory regions, as they carry binding sites for transcription factors (TFs).